%0 Journal Article
%T 美国国家健康及营养普查人群巨细胞病毒与癌症发生的相关性
%A 李森
%A 王嘉馨
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.18.0213
%X 摘要 目的 研究巨细胞病毒（CMV）的存在与癌症的关系。方法 回顾性分析1988—1994年参加国家健康及营养普查（NHANES Ⅲ）人群（年龄≥17岁）感染巨细胞病毒与患癌症的关系。结果 在来自NHANES Ⅲ的14 718名美国居民（≥17岁）中，CMV存在于有癌症史的患者中，皮肤癌及结直肠癌患者中稍高。CMV的加权流行率，女性较男性高出10%甚至更多，尤其在女性乳腺癌、宫颈癌及子宫癌等相关癌症中，CMV存在率稍高。且该流行率随着年龄的增长逐渐增加（P<0.01）。未经校正的逻辑回归分析表明，CMV的存在与癌症发生、皮肤癌和乳腺癌有相关性（P<0.01），但校正性别、年龄、教育背景、种族、贫困收入比率、身体质量指数及吸烟和饮酒状况等混杂因素后，该相关性不再显著。结论 巨细胞病毒的存在与癌症相关性不显著
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%U http://www.zlfzyj.com/CN/abstract/abstract9282.shtml