%0 Journal Article
%T 甲状腺微小乳头状癌术中快速病理形态学特点及临床分析
%A 冯曦
%A 方娜
%A 杨小玲
%A 谭雨萌
%A 郭芳
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.01.015
%X 摘要 目的 总结甲状腺微小乳头状癌术中快速大体标本及显微镜下的形态学特点，提高确诊率。方法 收集129例甲状腺术中快速及常规病理诊断为甲状腺微小乳头状癌的患者资料，包括术中肉眼观察标本大体描述、冰冻切片及术后常规病理诊断等，进行统计学分析。结果 （1）甲状腺微小乳头状癌病理诊断技术成熟术中快速诊断和常规石蜡切片诊断的符合率为97.67%；（2）大体标本观察肿瘤在左、右侧或双侧的发生率差异无统计学意义（34.9% vs. 38.0% vs. 27.1%, P=0.1630）；单个肿瘤直径≤0.5 cm组，明显多于直径＞0.5 cm组（63.6% vs. 36.4%, P=0.0000）差异有统计学意义；肿瘤发生1灶组、2灶组和2灶以上组比较，差异有统计学意义（84.5% vs. 8.5% vs. 7.0%, P=0.0000）；肿瘤质硬组明显多于质软组，差异有统计学意义（85.3% vs. 14.7%, P=0.0000）；切面白色组明显多于淡红组，差异有统计学意义（94.6% vs. 5.4%, P=0.0000）；伴随星形外观组明显多于不伴随星形外观组，差异有统计学意义（60.5% vs. 39.5%, P=0.0008）；基础病变为：结节性甲状腺肿组、桥本氏甲状腺炎组、其他病变组和腺瘤囊性变组的发生率呈依次递减的趋势，差异有统计学意义（48.1% vs. 22.5% vs.15.4% vs. 14.0%, P=0.0000）；（3）显微镜下术中快速切片中显著的纤维间质反应、硬化的背景上出现张力大扩张的腺体为诊断的重要线索，细胞核内假包涵体、砂粒体及钙化的存在可以辅助诊断。结论 术中快速切片为甲状腺微小乳头状癌诊断的重要技术手段，正确辨认肿瘤组织的大体及显微镜下特点，有利于提高诊断的准确性
%K A Meta-analysis
%K Role of miR-138 in Invasion of Human Colon Cancer Cells SW620 by Regulating PDK1 Expression
%K Clinical Observation of 46 Cases of Endoscopic Surgery for Thyroid Cancer Through Chest and Mammary Areola Approach
%K MicroRNA-31 Expression in Colorectal Cancer and Bioinformatic Analysis of Its Predicted Target Genes
%K Replication-deficient Adenovirus Carrying hsa-microRNA-149 Inhibits Proliferation of Human Hepatocellular Carcinoma Cell Lines
%K Clinicopathologic Analysis of Encapsulated Papillary Carcinoma of Breast
%K Clinical Value of miRNAs in Blood or Sputum as Biomarkers for Early Screening and Diagnosis of Lung Cancer
%K MicroRNA-184 Expression in Glioma Tissues and Its Prognosis Value
%K miR-133b Expression in Gastric Cancer and Related Significance
%K MicroRNAs Expression in Benign and Malignant Pleural Effusion
%K Clinical Application of Iodine-Enhanced Image of Dual-source Computed Tomography in Distinguishing Benign and Malignant Thyroid Nodules
%U http://www.zlfzyj.com/CN/abstract/abstract8685.shtml