%0 Journal Article
%T 晚期肺癌患者癌症相关性疲乏的发生及其与血清炎性因子的关系
%A 刘巍
%A 单玉洁
%A 吕雅蕾
%A 周欣亮
%A 常靓
%A 王玉栋
%A 王龙
%A 陈红姗
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.06.010
%X 摘要 目的 本研究拟评估晚期肺癌患者癌症相关性疲乏（cancer-related fatigue, CRF）发生情况，测定血清中CRP、CORT、IL-6的水平，探究该指标与CRF之间的相关性。方法 应用FACIT-F量表对51例晚期肺癌患者进行CRF评估。采用免疫比浊法测定血清CRP水平，免疫微粒电发光法测定CORT水平，采用双抗体夹心酶联免疫吸附ELISA法测定IL-6水平。采用Spearman相关分析方法分析量表得分与血清炎性因子水平的相关程度。应用Logistic回归分析进行危险因素分析。结果 27例患者附加关注子量表得分≤34分，CRF发生率为52.9%。存在疼痛的患者身体状况及附加关注得分低于无疼痛患者（P=0.009, P=0.018）。睡眠障碍显著影响身体状况、附加关注及总分值得分，存在睡眠障碍者三项得分均明显低于无睡眠障碍患者（P<0.01）。血清CRP水平与身体状况、功能状况、附加关注、总得分呈负相关（P值分别为0.004、0.027、0.007、0.013）。IL-6水平与身体状况、附加关注及总分值呈负相关（P值分别为0.044、0.029、0.023）。CORT水平与量表得分无显著相关。睡眠障碍和疼痛是CRF的独立危险因素，OR值分别为6.167、7.405（P=0.010, P=0.005）。结论 血清IL-6、CRP水平高低与患者疲乏程度显著相关，血清IL-6、CRP水平越高与患者疲乏程度相关性越显著，IL-6、CRP可作为临床监测疲乏程度的指标。合并疼痛、睡眠障碍的患者更容易发生疲乏、疲乏程度更严重
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%U http://www.zlfzyj.com/CN/abstract/abstract8515.shtml