%0 Journal Article
%T 74例淋巴母细胞淋巴瘤的临床特点及预后分析
%A 岳智杰
%A 张翼鷟
%A 王晓芳
%A 臧立
%A 袁英
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0751
%X 摘要 目的 分析淋巴母细胞淋巴瘤（lymphoblastic lymphoma, LBL）的临床特点，比较B淋巴母细胞淋巴瘤（B lymphoblasts lymphoma, B-LBL）与T淋巴母细胞淋巴瘤（T lymphoblasts lymphoma, T-LBL）的临床及预后特点及不同化疗方案对LBL的预后影响。方法 选择2007—2014年天津医科大学肿瘤医院收治的74例经免疫组织化学确诊为LBL的患者。采用描述统计方法分析LBL的疾病谱特征。结果 74例LBL患者的中位年龄为19.5岁，其中45例为男性，60例为晚期起病（Ann-Arbor分期Ⅲ~Ⅳ期），42例存在B症状，32例发生骨髓受累。治疗总有效率为70.2%，完全缓解率为48.6%，3年和5年总生存率（overall survival, OS）分别为38.0%和26.6%，3年和5年无进展生存率（progression-free survival, PFS）分别为34.8%和23.2%。其中B-LBL患者17例，T-LBL患者57例。B-LBL较T-LBL更倾向发生于儿童，起病时多伴有贫血，二者生存意义比较差异无统计学意义。单因素分析显示年龄是否小于18岁、有无贫血、β2微球蛋白水平、诱导治疗方案、近期疗效为预后相关因素。结论 淋巴母细胞淋巴瘤是一种高度侵袭性的恶性非霍奇金淋巴瘤，生存期短，多发生于青少年，起病时多为晚期，易发生骨髓转移。采用ALL类化疗方案的患者预后可能优于CHOP样方案
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%U http://www.zlfzyj.com/CN/abstract/abstract9122.shtml