%0 Journal Article %T Light sheet imaging comes of age %A Claudette M. %A Claudette M. St. Croix %A Simon C. Watkins %A St. Croix %J JCB | The Journal of Cell Biology %D 2018 %R 10.1083/jcb.201804016 %X Light-sheet fluorescence microscopy methods that minimize photodamage are increasingly penetrant in biomedical research and currently comprise three distinct platforms. In this issue, Fadero et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201710087) describe a fourth approach termed ¡°LITE microscopy,¡± which is useful for extended imaging of specimens from cells to organisms. %U http://jcb.rupress.org/content/217/5/1567