%0 Journal Article
%T 污汛 T cells provide the early source of IFN-污 to aggravate lesions in spinal cord injury
%J JEM | The Journal of Experimental Medicine
%D 2018
%R 10.1084/jem.20170686
%X Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). 污汛 T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in 污汛 T cells (TCR汛ˋ/ˋ) showed improved functional recovery after SCI. 污汛 T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V污4 subtype and express the inflammatory cytokine IFN-污. Inactivating IFN-污 signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V污4 antibodies has a beneficial effect, similar to that obtained with anti每TNF-汐. In SCI patients, 污汛 T cells are detected in the CSF, and most of them are IFN-污 positive. In conclusion, manipulation of 污汛 T cell functions may be a potential approach for future SCI treatment.
%U http://jem.rupress.org/content/215/2/521