%0 Journal Article
%T Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-百B signaling
%J JEM | The Journal of Experimental Medicine
%D 2018
%R 10.1084/jem.20160659
%X M cells are located in the follicle-associated epithelium (FAE) that covers Peyer＊s patches (PPs) and are responsible for the uptake of intestinal antigens. The differentiation of M cells is initiated by receptor activator of NF-百B. However, the intracellular pathways involved in M cell differentiation are still elusive. In this study, we demonstrate that the NF-百B pathway activated by RANK is essential for M cell differentiation using in vitro organoid culture. Overexpression of NF-百B transcription factors enhances the expression of M cell每associated molecules but is not sufficient to complete M cell differentiation. Furthermore, we evaluated the requirement for tumor necrosis factor receptor每associated factor 6 (TRAF6). Conditional deletion of TRAF6 in the intestinal epithelium causes a complete loss of M cells in PPs, resulting in impaired antigen uptake into PPs. In addition, the expression of FAE-associated genes is almost silenced in TRAF6-deficient mice. This study thus demonstrates the crucial role of TRAF6-mediated NF-百B signaling in the development of M cells and FAE.
%U http://jem.rupress.org/content/215/2/501