%0 Journal Article
%T STAT-3¨Cindependent production of IL-17 by mouse innate-like ¦Á¦Â T cells controls ocular infection
%J JEM | The Journal of Experimental Medicine
%D 2018
%R 10.1084/jem.20170369
%X Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes tissue damage. Investigation of conventional CD4+ T cells (Th17 cells) has yielded invaluable insights into IL-17 function and its regulation. More recently, we and others reported production of IL-17 from innate ¦Á¦Â+ T cell populations, which was shown to occur primarily via IL-23R signaling through the transcription factor STAT-3. In our current study, we identify promyelocytic leukemia zinc finger (PLZF)¨Cexpressing iNKT, CD4£¿/CD8+, and CD4£¿/CD8£¿ (DN) ¦Á¦Â+T cells, which produce IL-17 in response to TCR and IL-1 receptor ligation independently of STAT-3 signaling. Notably, this noncanonical pathway of IL-17 production may be important in mucosal defense and is by itself sufficient to control pathogenic Staphylococcus aureus infection at the ocular surface.
%U http://jem.rupress.org/content/215/4/1079