%0 Journal Article %T IgA¡ªabout the unexpected %J JEM | The Journal of Experimental Medicine %D 2018 %R 10.1084/jem.20181153 %X In this issue of JEM, Nakajima et al. (https://doi.org/10.1084/jem.20180427) demonstrate that glycan-dependent, epitope-independent IgA coating of intestinal bacteria alters bacterial gene expression and metabolism. This conferred coated bacteria with fitness within the mucus niche and contributed to intestinal homeostasis through cross-phylum interactions. %U http://jem.rupress.org/content/215/8/1965