%0 Journal Article
%T One domain fits all: Using disordered regions to sequester misfolded proteins
%A Alberti
%A Boczek
%A Edgar E.
%A Edgar E. Boczek
%A Simon
%A Simon Alberti
%J JCB | The Journal of Cell Biology
%D 2018
%R 10.1083/jcb.201803015
%X Small heat shock proteins (sHsps) are adenosine triphosphate¨Cindependent chaperones that protect cells from misfolded proteins. In this issue, Grousl et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708116) show that the yeast sHsp Hsp42 uses a prion-like intrinsically disordered domain to bind and sequester misfolded proteins in protein deposition sites.
%U http://jcb.rupress.org/content/217/4/1173