%0 Journal Article
%T Genetic models reveal origin, persistence and non-redundant functions of IL-17每producing 污汛 T cells
%J JEM | The Journal of Experimental Medicine
%D 2018
%R 10.1084/jem.20181439
%X 污汛 T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, 污汛 T cell每deficient Tcrdˋ/ˋ mice display surprisingly mild phenotypes. We hypothesized that the lack of 污汛 T cells in constitutive Tcrdˋ/ˋ mice is functionally compensated by other lymphocytes taking over genuine 污汛 T cell functions. To test this, we generated a knock-in model for diphtheria toxin每mediated conditional 污汛 T cell depletion. In contrast to IFN-污每producing 污汛 T cells, IL-17每producing 污汛 T cells (T污汛17 cells) recovered inefficiently after depletion, and their niches were filled by expanding Th17 cells and ILC3s. Complementary genetic fate mapping further demonstrated that T污汛17 cells are long-lived and persisting lymphocytes. Investigating the function of 污汛 T cells, conditional depletion but not constitutive deficiency protected from imiquimod-induced psoriasis. Together, we clarify that fetal thymus-derived T污汛17 cells are nonredundant local effector cells in IL-17每driven skin pathology.
%U http://jem.rupress.org/content/215/12/3006