%0 Journal Article %T The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis %A Anantharam %A Arun %A Arun Anantharam %A Chon %A Daniel D. %A Daniel D. MacDougall %A Hai %A Hai Lin %A Jackman %A Jefferson D. %A Jefferson D. Knight %A Knight %A Lin %A MacDougall %A Nara L. %A Nara L. Chon %A Skyler L. %A Skyler L. Jackman %A Zesen %A Zesen Lin %J JGP | The Journal of General Physiology %D 2018 %R 10.1085/jgp.201711944 %X Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter release. Recently, Syt-7 has become a topic of broad interest because of its extreme calcium sensitivity and diversity of roles in a wide range of cell types. Here, we review the known and emerging roles of Syt-7 in various contexts and stress the importance of its actions. Unique functions of Syt-7 are discussed in light of recent imaging, electrophysiological, and computational studies. Particular emphasis is placed on Syt-7¨Cdependent regulation of synaptic transmission and neuroendocrine cell secretion. Finally, based on biochemical and structural data, we propose a mechanism to link Syt-7¡¯s role in membrane fusion with its role in subsequent fusion pore expansion via strong calcium-dependent phospholipid binding. %U http://jgp.rupress.org/content/150/6/783