%0 Journal Article
%T The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis
%A Anantharam
%A Arun
%A Arun Anantharam
%A Chon
%A Daniel D.
%A Daniel D. MacDougall
%A Hai
%A Hai Lin
%A Jackman
%A Jefferson D.
%A Jefferson D. Knight
%A Knight
%A Lin
%A MacDougall
%A Nara L.
%A Nara L. Chon
%A Skyler L.
%A Skyler L. Jackman
%A Zesen
%A Zesen Lin
%J JGP | The Journal of General Physiology
%D 2018
%R 10.1085/jgp.201711944
%X Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter release. Recently, Syt-7 has become a topic of broad interest because of its extreme calcium sensitivity and diversity of roles in a wide range of cell types. Here, we review the known and emerging roles of Syt-7 in various contexts and stress the importance of its actions. Unique functions of Syt-7 are discussed in light of recent imaging, electrophysiological, and computational studies. Particular emphasis is placed on Syt-7¨Cdependent regulation of synaptic transmission and neuroendocrine cell secretion. Finally, based on biochemical and structural data, we propose a mechanism to link Syt-7¡¯s role in membrane fusion with its role in subsequent fusion pore expansion via strong calcium-dependent phospholipid binding.
%U http://jgp.rupress.org/content/150/6/783