%0 Journal Article %T TRIMming TGF-¦Â signals in Th17 cells %J JEM | The Journal of Experimental Medicine %D 2018 %R 10.1084/jem.20180986 %X The precise downstream mediators of TGF-¦Â signaling in Th17 and T reg cells remain unclear. In this issue of JEM, Tanaka et al. report that Trim33 transduces TGF-¦Â signals in Th17 cells to generate an optimal proinflammatory cytokine profile. %U http://jem.rupress.org/content/215/7/1775