%0 Journal Article
%T Newly found arsons ignite the fire of gut GVHD
%A Defu Zeng
%J The Journal of Clinical Investigation
%D 2018
%R 10.1172/JCI98685
%X Acute graft-versus-host disease (GVHD) in the gut is common following hematopoetic cell transplantation (HCT) and is associated with high mortality. However, it remains unclear whether Th1 or Th17 CD4+ T cells can initiate acute gut GVHD. In this issue of the JCI, Ullrich and colleagues identified a subset of CD4+ T cells that express high levels of IL-7R¦Á and granulocyte-macrophage CSF (IL-7R¦ÁhiGM-CSF+) cells that are involved in the induction of acute gut GVHD in murine models. The IL-7R¦ÁhiGM-CSF+ effector memory cells were BATF dependent, ROR¦Ãt independent, produced large amounts of GM-CSF and IFN-¦Ã, and released little IL-17. CD4+IL-7R¦ÁhiGM-CSF+ cells were not classical Th17 cells but had more of a Th1-like phenotype, despite their dependence on BATF. This work suggests that targeting the IL-7R/BATF/GM-CSF axis has therapeutic potential for treating acute gut GVHD
%U https://www.jci.org/articles/view/98685