%0 Journal Article %T Global Breast Cancer Research: Moving Forward %A Carlos H. Barrios %A Gustavo Werutsky %A Tom¨¢s Reinert %J About the Ed Book | ASCO Educational Book %D 2018 %R https://doi.org/10.1200/EDBK_209183 %X Current projections indicate that the number of new cancer cases is increasing at a fast rate and will evolve from 14 million global cases in 2012 to 22 million by 2030, with the majority of cases occurring in LMICs.1 There are approximately 1.67 million new cases of breast cancer diagnosed annually, and breast cancer mortality is second only to lung cancer.2 It is noteworthy that although incidence rates are increasing in most countries, mortality rates are decreasing only in high-income countries, with an estimated 70% of breast cancer deaths occurring in LMICs.1,3 Recently reported data from the United States show a 26% decrease in overall cancer mortality over the last 2 decades; breast cancer deaths declined by 39% from 1991 to 2015.4 Although advances in screening, early detection, and adjuvant treatment are mostly responsible for the decline in mortality in high-income countries, most new cases are recorded in LMICs, where rates of death from breast cancer are increasing.5 Although major advances in our understanding of the disease have revolutionized our approach to treatment, guided by the introduction of genomic testing platforms, anti-HER2, aromatase inhibition, and anti-CDK4/6 therapies, substantial challenges remain in the management of some resistant forms of the disease.6-8 In the early-stage setting, substantial improvement in breast cancer relapse-free survival rates over the last several decades have been reported, especially in HER2-positive and triple-negative tumors.9 Results in the metastatic setting, however, leave room for improvement. Recently presented real-world data from France indicate substantial progress in the outcome of patients with metastatic HER2-positive disease, but show no improvement in the 5-year survival of patients with tumors that are HER2-negative, HR-positive and triple-negative.10 ADDRESSING BASIC GLOBAL NEEDS Section: ChooseTop of pageAbstractADDRESSING BASIC GLOBAL N... <