%0 Journal Article
%T Microfluidic Radiosynthesis of the Muscarinic M2 Imaging Agent [18F]FP-TZTP*
%A Giancarlo Pascali
%A Ivan Greguric
%A Lidia Matesic
%J Australian Journal of Chemistry
%D 2018
%R 10.1071/CH18266
%X Abstract 3-(4-(3-[18F]Fluoropropylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyridine ([18F]FP-TZTP) is a selective 18F-radiotracer for the muscarinic acetylcholine receptor subtype M2, which can be used to perform positron emission tomography (PET) scans on patients with neurological disorders such as Alzheimer¡¯s disease. [18F]FP-TZTP was produced using continuous-flow microfluidics, a technique that uses reduced amounts of chemical reagents, shorter reaction times and in general, results in higher radiochemical yields compared to currently used techniques. The optimal 18F-radiolabelling conditions consisted of a total flow rate of 40£¿¦ÌL£¿min£¿1 and 190¡ãC, which produced [18F]FP-TZTP in 26£¿¡À£¿10£¿% radiochemical yield with a molar activity of 182£¿¡À£¿65 GBq ¦Ìmol£¿1 and >99£¿% radiochemical purity.
%U http://www.publish.csiro.au/CH/fulltext/CH18266