%0 Journal Article %T A C. briggsae Genetic Suppressor Screen to Identify Dosage Compensation Pathway Components | Insight Medical Publishing %A August P Miguez %A Jacqueline C Alex %A Jason E Webb %A Jihye Lee %A Te-Wen Lo %A er %J Journal Impact Factor: 1.48 %D 2018 %R 10.21767/2471-8084.100066 %X Dosage compensation, the process by which the expression of X-linked genes are equalized between males, which have a single X chromosome and females, which have two, is essential in all heterogametic organisms. In C. elegans, dosage compensation is a complex process that is regulated by the developmental switch gene, xol-1. To better our understanding of the evolution of dosage compensation in nematodes, we use C. briggsae which has diverged from C. elegans ~15-30 million years ago, as a comparative model organism. In both species, loss of xol-1 results in a male specific lethality phenotype. We exploited this phenotype in C. briggsae and performed a classic genetic suppressor screen and identified nine suppressor mutations that are likely to represent components in the C. briggsae dosage compensation pathway. %U http://biochem-molbio.imedpub.com/a-c-briggsae-genetic-suppressor-screen-to-identify-dosage-compensationpathway-components.php?aid=23120