%0 Journal Article
%T Expression Level of Plasma Soluble Toll like Receptor 2 and 6 in the Mother to
Child Transmission of Human Immunodeficiency Virus Type 1 | Insight Medical Publishing
%A Alexis Ndjolo
%A C¨Śline Nguefeu Nkenfou
%A Jacques Henri Th¨¨ze
%A Jules Roger Kuiat¨Ś
%A Linda Chapdeleine Mouafo Mekue
%A Marie Nicole Ngoufack
%A Vittorio Colizzi
%J Journal Impact Factor: 1.48
%D 2018
%R 10.21767/2471-8084.100059
%X Background and context: Dysregulation of the immune system by the Human immunodeficiency virus (HIV) has an impact on innate immune components such as Toll-like receptors (TLRs). Objective: We looked at the plasma concentration of soluble TLR2 and sTLR6 in mother-to-child transmission. Methods: Two hundred and eighty three mothers with their newborn were recruited. Mothers were classified into five groups: transmitter with prevention (TWP), transmitter without prevention (TWDP), non-transmitter with prevention (NTWP), non-transmitter without prevention (NTWDP) and controls. MothersĄŻ blood samples were collected in EDTA tubes. Levels of sTLR2/6 were determined using sandwich enzyme-linked immunosorbent assays. HIV status of new-born was determined using PCR-DNA on dried blood spots. Results: HIV infected mothers have a statistically higher level of sTLR2 than HIV non-infected mothers (p=0.001). The highest concentration was found in the NTWDP >TWP >NTWP >TWDP. There was a significant difference between all the medians comparing groups two by two. For sTLR6 there was neither a significant difference (p=0.156) between HIV infected and non-infected mothers, nor between groups. The median concentration was higher in NTWDP > NTWP > TWP > TWDP. Conclusion: sTLR2 and sTLR6 plasma concentration may be associated to the prevention of mother-to-child transmission. But antiretroviral treatment could also dim down this protective effect.
%U http://biochem-molbio.imedpub.com/expression-level-of-plasma-soluble-toll-like-receptor-2-and-6-in-the-mother-tochild-transmission-of-human-immunodeficiency-virus-t.php?aid=22155