%0 Journal Article
%T Differential Desensitisation of Afferent Nerve
Fibres by Iberis amara (STW 6) and Iberogast
(STW 5) in the Murine Colon | Insight Medical Publishing
%A Abdel AH
%A Hering N
%A Kasparek MS
%A Kreis ME
%A Mueller MH
%A Seeliger H
%J Journal Impact factor
%D 2018
%X Spontaneous afferent discharge was not different among the subgroups. STW 6 reduced afferent nerve discharge following 5-HT administration to 0.2 ¡À 0.2 imp seca£¿£¿1 compared to 3.0 ¡À 1.0 imp seca£¿£¿1 following STW 5 and 5.0 ¡À 2.0 imp seca£¿£¿1 in vehicle controls (p<0.05 STW 6 vs. vehicle). There was no difference in the response to bradykinin after addition of STW6 (36.0 ¡À 5.0 imp sec-1) and vehicle (38.0 ¡À 6.0 imp seca£¿£¿1), respectively, while this was reduced to 9.0 ¡À 2.0 imp seca£¿£¿1 following STW 5 (p<0.05 compared to vehicle). Afferent discharge to luminal ramp distension up to 80 cmH2O was reduced following STW 5 and STW 6 pre-treatment compared to vehicle (p<0.05). At high-threshold distension pressures a more pronounced reduction was observed following STW 5.
%U http://www.imedpub.com/articles/differential-desensitisation-of-afferent-nervefibres-by-iberis-amara-stw-6-and-iberogaststw-5-in-the-murine-colon.php?aid=21791