%0 Journal Article
%T Hormonal, Metabolic and Radiological Markers of Subclinical Atherosclerosis in Egyptian Children with Type 1 Diabetes | Insight Medical Publishing
%A Amal Elsayed
%A Hassan A. Shora
%A Hoda A Atwa
%J Reports in Endocrine Disorders: Open Access
%D 2018
%X Endothelial dysfunction may be a critical early target for preventing atherosclerosis and cardiovascular disease. Leptin/adiponectin ratio can serve as a clinical marker of endothelial dysfunction in children with type 1 diabetes. We investigated the relationship between leptin/adiponectin ratio with carotid intima-media thickness cIMT and endothelial dysfunction in 68 type 1 diabetic children mean age 8-14 years compared to 68 healthy control subjects matched for age, sex and body mass index. A serum level of leptin was measured via radioimmunoassay and adiponectin level was measured using an enzyme linked immunosorbent assay. Flow Mediated Dilatation was significantly correlated with leptin 9.906 ¡À 1.688 ng/dl and leptin/adiponectin L/A ratio r -0.301, p=0.079 but not with adiponectin. Statistically significant correlation was found between carotid intima media thickness and L/A ratio (r-0.274 P=0.026), leptin (r- 0.302 P=0 .012) and adiponectin (r -0.301 P=0.079). BMI was strongly statistically correlated with cIMT. CIMT, FMD, L/A ratio, and BMI may be useful surrogate markers of subclinical atherosclerosis that make early preventive interventional strategies feasible in type 1 diabetic children.
%U http://www.imedpub.com/articles/hormonal-metabolic-and-radiological-markers-of-subclinical-atherosclerosis-in-egyptian-children-with-type-1-diabetes.php?aid=23456