%0 Journal Article
%T Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid) | Insight Medical Publishing
%A Abdelfattah Zakhama
%A Ghada Souid
%A Naceur A. Boughattas
%A Nouha Souayed
%A Zohra Haouas
%J Researchgate Journal Impact: 0.23*; Journal Impact Factor: 1.91;
%D 2018
%R 10.21767/2248-9215.100070
%X Background: Isoniazid is a drug largely used for both the treatment and prophylaxis of Tuberculosis. In this study, we investigated whether INH-induced nephrotoxicity is influenced by dosing-time. Materials and Methods: A potentially toxic INH dose (120 mg/kg) was injected by i.p. route to different groups of animals at three different circadian times: 1, 9 and 17 hours after light onset (HALO). INH administration at 1 and 9 HALO resulted in maximum and minimum nephrotoxicity respectively. Toxicity was assessed by the significant increase in both biochemical parameters of kidney function (Urea: URE, Uric Acid: URI and Creatinine: CERT) and stress oxidative (Malondialdehyde: MDA). These results were correlated with the severe and minor renal histopathological observed at 1 and at 9 HALO respectively. Conclusion: The optimal tolerance or least side effects were detected when INH was injected in the second part of the light-rest span (9 HALO) of mice.
%U http://www.imedpub.com/articles/temporal-variation-in-murine-kidney-toxicity-to-the-antituberculosis-agent-isoniazid.php?aid=23251