%0 Journal Article
%T Deficiency of 污汛T cells protects against abdominal aortic aneurysms by regulating phosphoinositide 3-kinase/AKT signaling - Journal of Vascular Surgery
%A Bin You
%A Congcong Zhang
%A Guang Li
%A Jie Du
%A Ping Li
%A Shuai Zhang
%A Xiaoyu Kan
%A Yulin Li
%J Journal of Vascular Surgery Home Page
%D 2018
%R https://doi.org/10.1016/j.jvs.2016.03.474
%X It is known that T lymphocytes are activated in human abdominal aortic aneurysms (AAAs). 污汛T cells, as a subset of T cells, play a role in many inflammation-related diseases. However, whether 污汛T cells participate in the formation of AAA remains unknown. In this study, we explored the role of 污汛T cells in AAA lesions. Using the porcine pancreatic elastase-induced AAA model, we found that knock out of 污汛T cells significantly attenuated AAA formation. To elucidate how 污汛T cells contribute to AAA, microarray analysis was performed, which found that the phosphoinositide 3-kinase/AKT signaling pathway was activated in elastase-perfused 污汛T knockout (污汛T KO) mice. By studying differentially expressed genes involved in phosphoinositide 3-kinase signaling, we found that proliferation-related genes (Sos1, Mtor, Myc) were upregulated whereas apoptosis-related genes (Pten, Bcl1, Bad) were downregulated in elastase-perfused 污汛T KO mice. Furthermore, histopathologic analysis showed increased PCNA+ and decreased TUNEL+ cells in elastase-perfused 污汛T KO mice compared with wild-type mice. In addition, inflammatory cytokines including interleukin-1汕, Mcp-1, and tumor necrosis factor-汐 were downregulated in the aneurysm tissues of elastase-perfused 污汛T KO mice. These data reveal a pathogenic role of 污汛T cells in the experimental AAA model, likely through mechanisms regulating cell proliferation and mediating inflammatory response. Thus, targeting of 污汛T cells may offer a potential therapeutic method for aortic aneurysms. Abdominal aortic aneurysm (AAA) is now considered to be an inflammatory disease. Despite numerous advances in therapeutic strategies, the mortality rate still remains high because of the progressive expansion and sudden rupture. Increasing evidence has demonstrated an important role of inflammatory response in mouse models of AAA. It has been proved that AAA formation is accompanied by infiltration of T lymphocytes. In this study, we proved the functions of 污汛T cells regulating inflammation, cell proliferation, and apoptosis. Taken together, our findings suggested that the 污汛T cell is crucial for the development of AAA and may offer a potential therapeutic target for aortic aneurysm.
%U https://www.jvascsurg.org/article/S0741-5214(16)31854-7/fulltext