%0 Journal Article
%T Singleton fetal growth kinetics depend on the mode of conception - Fertility and Sterility
%A Bouchra Khallouk
%A C谷cile Choux
%A C谷line Bruno
%A Julie Barberet
%A Karine Astruc
%A Patricia Fauque
%A Paul Sagot
%A Perrine Ginod
%A Thierry Rousseau
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.06.030
%X To study the impact of in vitro fertilization, with or without intracytoplasmic sperm injection (IVF/ICSI), frozen-embryo transfer (FET), and intrauterine insemination (IUI) on fetal growth kinetics throughout pregnancy and to compare the different modes of conception. Retrospective cohort study. University. A total of 560 singleton pregnancies were included (96 IVF, 210 ICSI, 121 FET, and 133 IUI). None. We compared crown-rump length (CRL) at the first trimester (T1: 11每13 weeks of gestation [WG] + 6 days), estimated fetal weight (EFW) at the second (T2: 21每23 WG + 6 days) and third (T3: 31每33 WG + 6 days) trimesters, and birth weight (BW) z-scores with those in the reference curves (Papageorghiou for T1, and Ego M2 for T2, T3, and birth). Multivariate analyses were performed. For T1, the CRL was longer than the reference curve whatever the assisted reproductive technique (ART). For T2, EFW was significantly greater for all groups compared with the reference curve, and for T3 only FET singletons had a greater EFW. ICSI, IVF, and IUI singletons had a significantly lower BW compared with reference curves. For all ART fetuses, growth kinetics differed from T2. Only FET fetuses maintained their significantly above-reference growth values. The proportion of fetuses for which at least one period of growth loss was observed from T2 to birth was higher after IVF, ICSI, and IUI than after FET. For the first time, we have highlighted that fetal growth kinetics differed from T2 depending on the ART protocols used. They could have an impact on trophoblastic invasiveness and might lead to long-term health effects. Las cin谷ticas de crecimiento de un feto 迆nico dependen del m谷todo de concepci車n Estudiar el impacto de la fecundaci車n in vitro con o sin inyecci車n intracitopl芍smica de espermatozoides (IVF/ICSI), transferencia de embriones congelados (FET) e inseminaci車n intrauterina (IUI), en la cin谷tica de crecimiento fetal durante el embarazo, y comparar los diferentes m谷todos de concepci車n. Estudio de cohorte retrospectivo. Universidad. Se incluyeron un total de 560 gestaciones con feto 迆nico (96 IVF, 210 ICSI, 121 FET y 133 IUI). Ninguna. Comparamos la longitud c谷falo caudal (CRL) en el primer trimestre (T1: 11每13 semanas de gestaci車n [WG]) + 6 d赤as), el peso fetal estimado (EFW) en el segundo (T2: 21 每23 WG + 6 d赤as) y tercer (T3: 31每33 WG + 6 d赤as) trimestres, y los z-scores del peso al nacer (BW) con los de las curvas de referencia (Papageorghiou para T1, y Ego M2 para T2, T3, y nacimiento). Se realizaron an芍lisis multivariados. Para T1, el CRL fue m芍s largo que
%U https://www.fertstert.org/article/S0015-0282(18)30540-5/fulltext