%0 Journal Article
%T Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway
%A Bo Tu
%A Guangming Li
%A Haisheng Yu
%A Hongbo Wang
%A Juanjuan Zhao
%A Liang Cheng
%A Liguo Zhang
%A Lishan Su
%A Qi Wang
%A Qiang Fu
%A Weiwei Chen
%A Xin Zhang
%A Yanling Sun
%A Zheng Zhang
%A Zhenwen Liu
%J -
%D 2018
%R 10.1371/journal.ppat.1006819
%X Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+ and CD4- subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore, chronic HIV-1 infection activated and depleted both CD4+ and CD4- ILC1s, and impaired their cytokine production activity. Highly active antiretroviral (HAART) therapy in HIV-1 patients efficiently rescued the ILC1 numbers and reduced their activation, but failed to restore their functionality. We also found that blocking type-I interferon (IFN-I) signaling during HIV-1 infection in vivo in humanized mice prevented HIV-1 induced depletion or apoptosis of ILC1 cells. Therefore, we have identified the CD4+ ILC1 cells as a new target population for HIV-1 infection, and revealed that IFN-I contributes to the depletion of ILC1s during HIV-1 infection
%K HIV-1
%K Highly-active antiretroviral therapy
%K Mouse models
%K T cells
%K Blood
%K Cytotoxic T cells
%K Cytokines
%K Lymphoid organs
%U https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006819