%0 Journal Article
%T Association of Epstein-barr Virus With Gastric Carcinoma Among Sudanese Patients - Association of Epstein-barr Virus With Gastric Carcinoma Among Sudanese Patients - Open Access Pub
%A Dalia salahddin
%A Hassan Hussein Musa
%A Hosham abdalrahman
%A Ibtihal omer
%A Mona Ahmed
%J OAP | Home | Journal of Cancer Genetics And Biomarkers | Open Access Pub
%D 2017
%X Background: Gastric cancer (GC) ranks as the fourth most common cancer and the second leading cause of cancer deaths worldwide. Epstein-Barr virus is a well-known oncogenic virus, it is responsible for 10% of gastric carcinomas across the world. The aim of study was to determine the prevalence of EBV associated with GC in Sudanese patients. Method: Fifty Paraffin embedded blocks of gastric biopsy specimens diagnosed as gastric carcinoma were collected from Soba university hospital and Ribat teaching hospital, Khartoum, Sudan. DNA was extracted from the paraffin-embedded tissue, and then Epstein-Barr virus gene was detected by polymerase chain reaction (PCR). Result: Among the gastric biopsy specimens 27 (54.0%) were of male and 23(46.0%) were of female. Eleven EBV positive samples were found in gastric carcinomas (22.0%), 8 (72.7%) were of male and 3(27.2%) were of female. The mean age of the patients was 56 years, the most positive cases were between 50-59 years old, and (10%) of them are alive in Khartoum. Conclusions: There exists an association between EBV and gastric carcinoma in some Sudanese patients. Gastric cancer (GC) ranks as the fourth most common cancer and the second leading cause of cancer deaths worldwide. Epstein-Barr virus is a well-known oncogenic virus, it is responsible for 10% of gastric carcinomas across the world. The aim of study was to determine the prevalence of EBV associated with GC in Sudanese patients. Fifty Paraffin embedded blocks of gastric biopsy specimens diagnosed as gastric carcinoma were collected from Soba university hospital and Ribat teaching hospital, Khartoum, Sudan. DNA was extracted from the paraffin-embedded tissue, and then Epstein-Barr virus gene was detected by polymerase chain reaction (PCR). Among the gastric biopsy specimens 27 (54.0%) were of male and 23(46.0%) were of female. Eleven EBV positive samples were found in gastric carcinomas (22.0%), 8 (72.7%) were of male and 3(27.2%) were of female. The mean age of the patients was 56 years, the most positive cases were between 50-59 years old, and (10%) of them are alive in Khartoum. There exists an association between EBV and gastric carcinoma in some Sudanese patients. DOI10.14302/issn.2572-3030.jcgb-16-1190 Cancer is the one of leading cause of death in developed and developing countries 1. In 2012 about 14 million new cases and 8 million of cancer related deaths was recorded 2.Gastric cancer (GC) ranks as the fourth most common cancer and the second leading cause of cancer death worldwide. According to a global estimation, approximately 985,600 new
%U https://www.openaccesspub.org/jcgb/article/372