%0 Journal Article
%T New Antioxidant Flavonoids From the Aerial Parts of Secamone Afzelii - New Antioxidant Flavonoids From the Aerial Parts of Secamone Afzelii - Open Access Pub
%A Abdulmagid Alabdul Magid
%A Claire Mairot
%A Diane Patricia Apie Gossan
%A Laurence Voutquenne-Nazabadioko
%A Philom¨¨ne Akoua Yao-Kouassi
%J OAP | Home | Journal of Antioxidant Activity | Open Access Pub
%D 2018
%X A bioassay-guided fractionation of petroleum ether, EtOAc and n-BuOH soluble parts of the 80% hydromethanol extract was performed to investigate the antioxidant activity of Secamoneafzeliiaerial parts using DPPH free radical scavenging assay. The results revealed that EtOAc and n-BuOH soluble parts have moderate to good DPPH radical scavenging activity (EC50 = 139.3 and 30.5 ¦Ìg/mL, respectively). Therefore, from the most active fractions of EtOAc and n-BuOH soluble parts were isolated two new flavonoid diglycosides quercetin-3-O-¦Â-d-apiofuranosyl-(1¡ú2)-¦Á-l-rhamnopyranoside and genkwanin-8-C-¦Â-d-apiofuranosyl-(1¡ú2)-¦Â-d-glucopyranoside in addition to nine known compounds (2-10). Their structures were elucidated on the basis of spectroscopic data including 1D- and 2D-NMR and ESI-MS. The ability of the isolated compounds to scavenge the DPPH was evaluated. The new compound 1, quercitrin (3) and rutin (6) have antioxidant potential with EC50 values ranging from 8.4 to 13.6 ¦Ìg/mL, compared to the standard ascorbic acid (EC50 7.4 ¦Ìg/mL). DOI10.14302/issn.2471-2140.jaa-15-887 Antioxidants are compounds that inhibit or delay the oxidation process by blocking the initiation or propagation of oxidizing chain reaction due to oxidative stress 1. Antioxidants were known as free radical scavengers, reducing agents, chelators of pro-oxidant metals, or as quenchers of singlet oxygen. Described as an imbalance between free radicals and the body¡¯s ability to detoxify these molecules or repair the resulting damage, oxidative stress causes extensive damage to biological molecules such as DNA, lipids and proteins 2, 3. Thus, it is the cause of several diseases including cancer, cataracts, amyotrophic lateral sclerosis, accelerated aging, the acute respiratory distress syndrome and pulmonary oedema 4, 5. In order to provide a solution to this problem, we propose to contribute to the search for new antioxidants from indigenous natural sources 6, 7, 8. In our continued search for new bioactive compounds from Ivory Coast medicinal plants 8, we investigated Secamoneafzelii (Roem. and Schult.) K. Schum, a creeping woody climber belonging to the family Apocynaceae 9. S. afzeliiis used in traditional medicine for stomach problems, diabetes, colic, dysentery and also for kidney problems 10. The decoction of the entire plant is prescribed for cough, catarrhal conditions and as galactogogue. For the treatment of gonorrhoea, the whole plant is crushed with fresh palm nuts and oil 9. Previous studies have shown that S. afzelli has antioxidant, anti-inflammatory and antimicrobial
%U https://www.openaccesspub.org/jaa/article/238