%0 Journal Article
%T Preparation and Application For Separation of Small Molecules of A New Poly(ovs-co-edma) Hybrid Monolithic Column - Preparation and Application For Separation of Small Molecules of A New Poly(ovs-co-edma) Hybrid Monolithic Column - Open Access Pub
%A Aile Wei
%A Fengqing Wang
%A Haiyan Liu
%A Hongyuan Yan
%A Jing Zhao
%A Ligai Bai
%J OAP | Home | Journal of New Developments in Chemistry | Open Access Pub
%D 2018
%X A hybrid monolithic column was prepared using octavinyloctasilasesquioxane (OVS) as a monomer, benzoyl peroxide/dimethylacetamide (BPO/DMA) as initiator, ethylene glycol dimethacrylate (EDMA) as cross-linker, 1-dodecanol as porogenic agent and dimethylbenzene as cosolvent. A tidy skeleton, much bigger specific surface area (22.4 m2/g) and lower swelling property of the monolithic column with OVS added than the one without OVS added were determined with Scanning Electron Microscopy (SEM), Nitrogen adsorption/desorption measurements (BET) and swelling test with elute of different concentration of acetonitrile in water. Fourier-transform infrared spectra (FTIR) was taken to characterize the composition of groups. Moreover, a better separation performance for benzene series compounds under reversed phase liquid chromatography (RPLC) mode was obtained using the monolithic columns with OVS added than those without. DOI 10.14302/issn.2377-2549.jndc-15-923 Emerged in 1990s1, porous monolithic materials have been confirmed to be a good stationary phase for their straightforward fabrication, excellent permeability, high separation efficiency and other unique advantages to be used for separation of small molecules and biological matrix2, 3, 4, especially. Different from short-comings of traditional monolithic columns, the merits of hybrid monolithic columns including wide pH range tolerance, good mechanical stability, easy functionalization and high permeability enhanced its application5, 6, 7. That¡¯s because of the inorganic and organic components in hybrid polymers being linked together by covalent bonds. Such polymers are in fact molecular composites and are produced most often by the copolymerization of a monomer with an organically functionalized inorganic compound 8. With those merits mentioned above, hybrid monoliths have been applied in both online separation fields including capillary liquid chromatography (CLC)9, capillary electro-chromatography (CEC)4, 19, etc10. However, the process to prepare hybrid monolithic, the tediously condition-sensitive sol-gel and comprehensive polymerization, encumber their development and application 9. Polyhedral oligomeric silsesquioxanes (POSS), a series of cage-like three-dimensional oligomeric, organosilicon compounds, were used for the preparation of hybrid monoliths with free radical polymerization via ¡°one-pot¡± process11, 12 instead of the tedious and uncontrollable sol-gel procedure13, 14 in recent years. The periphery consisting of cage frameworks is covalently surrounded by organic groups, such as alkyl, vinyl,
%U https://www.openaccesspub.org/jndc/article/264