%0 Journal Article
%T Early Glycine Supplementation Re-establishes Adrenal Catecholamine Secretion in Hypothalamic Obesity Model in Rats But Does Not Affect Visceral Adiposity. - Early Glycine Supplementation Re-establishes Adrenal Catecholamine Secretion in Hypothalamic Obesity Model in Rats But Does Not Affect Visceral Adiposity. - Open Access Pub
%A Alexandre Silva Chaves
%A Ana Eliza Andreazzi
%A Carlos Alberto Mour£żo J¨²nior
%A Ernesto da Silveira Goulart Guimar£żes
%A Klaus Grossi Pettersen
%A Marcos Sacramento Silva
%A Paulo Cezar de Freitas Mathias
%A Ra¨²l Marcel Gonz¨˘lez Garcia
%A Santiago Tavares Paes
%A Silvioney Augusto da Silva
%A Tamiris Schaeffer Fontoura
%J OAP | Home | Journal of Glycomics And Metabolism | Open Access Pub
%D 2017
%X Obesity is a worldwide epidemic that features a multifactorial syndrome characterized by a chronic positive energetic unbalance. Neonatal administration of monosodium L-glutamate (MSG) causes lesion on the arcuate nucleus of hypothalamus that led to development of obesity in the adult life in rodents characterized by a notorious accumulation of catecholamine in the adrenal medulla. The amino acid glycine induces catecholamine secretion of adrenal medulla. Thus, the objective of our work was to evaluate the possible effects of glycine administration in the MSG-obesity model in rats and investigate its impact on adrenal catecholamine medulla homeostasis. Male Wistar rats received MSG solution (4mg/g body weight) subcutaneously in the cervical area for 5 days after delivery, controls received saline solution. Animals were also divided in two groups, in which one received tap water added with glycine (0.1g/Kg) after weaning on 21st day until 90 days of life.Biometrical variables, visceral fat pads weight, total content and basal secretion of adrenal cathecolamine were evaluated. Glycine increased Lee index of all tested groups and had no effect on visceral adiposity. However, glycine treatment completely reestablished catecholamine total content and basal secretion of MSG-obese group. In conclusion, although glycine treatment apparently completely reestablishes catecholamine secretion homeostasis it is not sufficient to significant directly reduce visceral adiposity in MSG obesity model in rats. DOI10.14302/issn.2572-5424.jgm-14-604 Obesity is a multifactorial syndrome characterized by a chronic positive energetic unbalance. Its incidence is increasing in alarming proportion; currently, approximately 500 million people are obese world-wide representing a risk factor for type 2 diabetes and cardiovascular illnesses 1, 2, 3, 4, 5. Extensive academic effort has been put on medical research to better understand the complexity of this disorder. The experimental obesity model induced by monosodium L-glutamate (MSG) has been widely used for being representative of the metabolic disturbance observed in human obesity 6. The neonatal administration of MSG causes lesion on the arcuate nucleus of hypothalamus 7, 8, 9. Neonatal administration of MSG led to development of obesity in the adult life in rodents 10, 11. Moreover, the animals develop an abnormal deposition of fat 12, 13, 14. Also, MSG-obese animals present hyperinsulinemia, insulin resistance and a notorious accumulation of catecholamines in the adrenal medulla due to impaired secretion process, among other
%U https://www.openaccesspub.org/jgm/article/184