%0 Journal Article
%T Biocompatible Scaffolds For Human-induced Pluripotent Stem Cell Transplantation and Modeling Post-stroke Recovery in Three-dimensional Neural Cell Culture - Biocompatible Scaffolds For Human-induced Pluripotent Stem Cell Transplantation and Modeling Post-stroke Recovery in Three-dimensional Neural Cell Culture - Open Access Pub
%A Joann Huynh
%A Lindsey Jager
%A Matthew B. Jensen
%J OAP | Home | Journal of Evolving Stem Cell Research | Open Access Pub
%D 2017
%X Human-induced pluripotent stem cells (HiPSCs) demonstrate promise in their ability to differentiate into neural cells and ultimately replace the cell types and thereby brain tissue damaged by stroke. This may diminish cognitive impairment due to stroke. Prior to transplantation, an appropriate scaffold must be determined to allow for heightened accuracy by facilitating proper adhesion, differentiation, and proliferation, increasing the likelihood of success, as will be defined in this review, in vivo. This paper aims to provide a review of available biocompatible scaffolds and their efficacy, to provide insight for future research utilizing clinical trials to study stem cell therapy as a form of post-stroke recovery. A systematic review of scaffolds outlined in full-text, peer-reviewed articles with unique experimental data, available on PubMed, will be conducted to determine an ideal scaffold, based on article and scaffold selection criteria best suited for the transplantation of human-induced pluripotent stem cells. DOI10.14302/issn.2574-4372.jesr-16-1055 Stroke is a leading cause of morbidity and mortality worldwide, costing the United States in particular, tens of billions of dollars annually in reduced productivity and hospitalizations.1 Currently, scientists are researching novel treatments for post-stroke recovery, integrating the fields of tissue engineering and stem cell research. Potential exists in the ability of stem cells to differentiate into neural cells and regenerate brain tissue damaged by stroke, thereby reducing cognitive impairment. Scaffold-mediated delivery of stem cells has been proven to result in greater control and success of transplantation.2 Scaffolds serve as a medium for delivering seeded cells into a bodily cavity, providing structural support, promoting cell-biomaterial interaction, facilitating cell adhesion, allowing for adequate exchange of gases, nutrients, and growth factors to ensure cell survival, proliferation, and differentiation, and limiting the immune response, thereby increasing the prospect of success in vivo.3 Therefore, research on the efficacy of available, biocompatible scaffolds is necessary to provide insight on which scaffold is best suited for use in seeding and transplanting stem cells, in order to evaluate the efficacy of stem cell therapy as a treatment for post-stroke recovery in clinical trials in the near future. This paper intends to compose and analyze the methods, and experimental results, if applicable, of research studies involving scaffolds that have met the selection criteria, and
%U https://www.openaccesspub.org/jesr/article/311