%0 Journal Article
%T Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)
%A Aaron Innocent Bogmis
%A Adrian Raducu Popa
%A Daniela Adam
%A Violeta Ciocaltei
%A Nicoleta Alina Guraliuc
%A Florin Ciubotaru
%A Ion-Christian Chiricu£¿£¿
%J International Journal of Medical Physics,Clinical Engineering and Radiation Oncology
%P 125-140
%@ 2168-5444
%D 2020
%I Scientific Research Publishing
%R 10.4236/ijmpcero.2020.93012
%X <strong>Introduction:</strong> Radiotherapy alone or combined with surgery and/or chemotherapy is being investigated in the treatment of malignant pleural mesothelioma (MPM). This study aimed to simulate a Volumetric Modulated Arc Therapy (VMAT) treatment of a patient with MPM. <strong>Materials and Methods:</strong> CT images from a patient with intact lungs were imported via DICOM into the Pinnacle3 treatment planning (TP) system (TPS) and used as a model for MPM to delineate organs at risk (OAR) and both clinical and planning target volumes (CTV and PTV) with a margin of 5 mm. Elekta Synergy with 6 MV photons and 80 leafs MLCi2 was employed. VMAT plans were generated using two coplanar arcs with gantry rotation angles of 178<span style=\"font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;\">&amp;deg</span> - 182<span style=\"font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;\">&amp;deg</span>, the collimator angles of each arc were set to 90<span style=\"font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;\">&amp;deg</span>, Octavius<span style=\"white-space:nowrap;\">&lt;sup&gt;&amp;reg;&lt;/sup&gt;</span> 4D 729 was employed for quality assurance while the calculated and measured doses were compared using VeriSoft. <strong>Results:</strong> A TP was achieved. The Gamma volume analysis with criteria of 3 mm distance to agreement and 3% dose difference yielded the gamma passing rate = 99.9%. The reference isodose was 42.75 Gy with the coverage constraints for the PTV D95 and V95 = 95.0% of 45 Gy. The remaining dosimetric parameters met the recommendations from the clinically acceptable guidelines for the radiotherapy of MPM. <strong>Conclusion:</strong> Using well-defined TV and VMAT, a consistent TP compared to similar ones from publications was achieved. We obtained a high agreement between the 3D dose reconstructed and the dose calculated.
%K Malignant Pleural Mesothelioma
%K Radiation Therapy
%K Radiotherapy
%K Volumetric Modulated Arc Therapy
%K VMAT
%K Target Volume Delineation
%K Treatment Planning
%K CTV
%K PTV
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=102181