%0 Journal Article
%T <i>In Situ</i> Characterization of Lopinavir by ATR-FTIR Biospectroscopy
%A Alireza Heidari
%J Computational Chemistry
%P 27-42
%@ 2332-5984
%D 2020
%I Scientific Research Publishing
%R 10.4236/cc.2020.83004
%X <p>
	Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 <span style=\"display:none;\" id=\"__kindeditor_bookmark_end_3__\"></span>and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared.
</p>
%K ATR-FTIR Biospectroscopy
%K Simulation
%K Lopinavir
%K Breakdown
%K Coronavirus Disease-2019
%K COVID-19
%K Infection
%K Protective and Therapeutic Effect
%K Potent Drug
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=101460