%0 Journal Article
%T Mouthwash with Active Oxygen (blue<sup>®</sup>m) Induces Keratinocytes Proliferation
%A Bruna Marca Mattei
%A Soraia A. W. Imanishi
%A Grasieli de Oliveira Ramos
%A Paloma Santos de Campos
%A Suyany Gabriely Weiss
%A Tatiana Miranda Deliberador
%J Open Journal of Stomatology
%P 107-114
%@ 2160-8717
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojst.2020.106012
%X <span>Chlorhexidine is widely used in dentistry to treat various gingival
conditions. Its side effects are widely described. Histologically, the gingiva
consists of a stratified squamous epithelium, with a predominance of
keratinocytes, the latter being fundamental in healing processes. Thus, the
objective of this </span><i><span>in vitro</span></i><span><span> study was
to evaluate the effects of a new product with active oxygen (blue<sup>&amp;#174;</sup></span><span>m) on
keratinocytes. Keratinocytes (HACAT) were incubated with different
concentrations of blue</span><span style=\"color:#4F4F4F;\"><span style=\"color:#4F4F4F;\"><span style=\"color:#393939;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:normal;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><sup><span style=\"font-size:10px;white-space:normal;\">&amp;#174;</span><span style=\"font-size:10px;white-space:normal;\"></span></sup></span></span></span></span></span></span></span></span></span><span>m (1, 10 and 100 ¦Ěl/ml), and another well was used as a
control, without the presence of mouthwash. After 24, 48 and 72 hours, cell
proliferation was analyzed by CyQUANT</span><span style=\"color:#4F4F4F;\"><span style=\"color:#4F4F4F;\"><span style=\"color:#393939;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:normal;\"><span style=\"white-space:nowrap;\"><sup style=\"vertical-align:super;\"><span style=\"white-space:nowrap;\"><sup><span style=\"font-size:10px;white-space:normal;\">&amp;#174;</span><span style=\"font-size:10px;white-space:normal;\"></span></sup></span></sup></span></span></span></span></span></span></span></span><span><span><span>. It was possible to observe that lower
concentrations (1 ¦Ěl/ml) of blue</span><span style=\"color:#4F4F4F;\"><span style=\"color:#393939;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:normal;\"><span style=\"white-space:nowrap;\"><span style=\"white-space:nowrap;\"><sup><span style=\"font-size:10px;white-space:normal;\">&amp;#174;</span><span style=\"font-size:10px;white-space:normal;\"></span></sup></span></span></span></span></span></span></span></span><span></span></span><span>m increased cell proliferation in HACAT cell
lines, while moderate and higher concentrations of mouthwash may present a
cytotoxic effect. This is the first
%K Keratinocytes
%K Cell Proliferation
%K Oxygen
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=100593