%0 Journal Article
%T Synthesis and Radiation Dosimetry of [<sup>68</sup>Ga]-Ga-Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology
%A Juan C. Manrique-Arias
%A Quetzali Pitalua-Cortes
%A Roberto Pedrero-Piedras
%A G¨¦iser Rodr¨ªguez-Mena
%A Tessy L¨®pez
%A Cristian Cabezas-Ortiz
%A Osvaldo Garc¨ªa-P¨¦rez
%J Journal of Encapsulation and Adsorption Sciences
%P 29-41
%@ 2161-4873
%D 2020
%I Scientific Research Publishing
%R 10.4236/jeas.2020.102002
%X This
Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP
receptors (GRPR), is over- expressed
in early stages of androgen-dependent prostate carcinomas, but not in advanced stages.
Therefore, there is a need to develop effective tracers for the accurate and
specific detection of this disease. The objective of this study was to evaluate
Lys<sup>1</sup>, Lys<sup>3</sup>-DOTA-BBN (1,14) analog with the radiolabeled
positron emitter [<sup>68</sup>Ga]-Ga-BBN for receptor imaging with PET, and to
determine its biodistribution and radiation dosimetry using whole-body (WB) PET
scans in healthy volunteers. The highest uptake was in the pancreas, followed
by urinary bladder. The critical organ was pancreas with a mean absorbed dose
of 206 ¡À 0.7, 210 ¡À 0.7, 120 ¡À 0.9, 390.23 ¡À 0.6 ¦ÌGy/MBq and the effective
doses were estimated as 73.2 ¡À 0.6, 49.8 ¡À 0.3 ¦ÌGy/MBq (women and men,
respectively).
%K Radiation Dosimetry
%K Biodistribution
%K PET Imaging
%K Radiopharmaceutical
%K Lys&lt
%K sup&gt
%K 1&lt
%K /sup&gt
%K Lys&lt
%K sup&gt
%K 3&lt
%K /sup&gt
%K -DOTA-BBN (1
%K 14)
%K Bombesin Analogs
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=101032