%0 Journal Article
%T Bacteriologically Confirmed Neuromeningeal Tuberculosis at the Hubert Koutoukou Maga National Hospital and University Center in Cotonou: About Two Cases Study and a Review of the Literature
%A Ang¨¨le Azon-Kouanou
%A Kouessi Anthelme Agbodande
%A Leoubou Roger Samuel Dodo
%A Mahoutin Semassa Ghislain Missiho
%A Roberto Dossou Tor¨¨s Kouassi Prudencio
%A Delphin Murhula
%A Marius Doukpo
%A Eug¨Śnie Dansou
%A Thomas Lokossou
%A Djimon Marcel Zannou
%A Fabien Fabien
%J Open Journal of Internal Medicine
%P 190-197
%@ 2162-5980
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojim.2020.102020
%X Introduction: Tuberculosis remains a major public health problem. The damage to the central nervous system is severe. We reported here two cases. Clinical Case 1: A 37-year-old female patient, naively Human Immunodeficiency Virus1 (HIV1)-positive with antiretroviral (ARV) treatment, hospitalized in the Internal Medicine department for altered consciousness in a febrile context. The clinical examination at admission noted a meningeal syndrome. Cytological analysis of the cerebrospinal fluid (CSF) revealed lymphocytic meningitis with 98% lymphocytes for 3634 leukocytes. CSF polymerase chain reaction (PCR) detected <i>Mycobacterium tuberculosis</i> DNA. She was put on anti-tuberculosis treatment. The immediate course was favourable, but a secondary worsening of the clinical picture was the cause of his death. Clinical Case 2: A 34-year-old male patient, naively HIV1-positive with ARV treatment. He is hospitalized in the Multi-Purpose Anaesthesia and Resuscitation Department of the CNHU HKM for altered consciousness in a feverish context. The clinical examination noted a meningeal syndrome. The cytological analysis of the CSF noted 184 leukocytes for 99% lymphocytes. The CSF PCR identified the DNA of <i>Mycobacterium tuberculosis</i>. He was put on anti-tuberculosis treatment. The evolution was marked by his death. Conclusion: The neuromeningeal localization of tuberculosis is a poor prognosis. Co-infection with HIV remains a potential deadly combination.
%K Neuromeningeal Tuberculosis
%K HIV Infection
%K Death
%K Cotonou
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=100301