%0 Journal Article %T Evolution of Graves¡¯s Disease: Impact of Socio-Demographic and Clinical Factors in Senegalese Subject %A Djiba Boundia %A Diedhiou Demba %A Sow Djiby %A Ndour Michel Assane %A Diallo Ibrahima Man¨¦ %A Barrage Ahmed Limane %A Ka-Ciss¨¦ Mariama %A Sarr Anna %A Ndour-Mbaye Maimouna %J Open Journal of Internal Medicine %P 160-170 %@ 2162-5980 %D 2020 %I Scientific Research Publishing %R 10.4236/ojim.2020.102017 %X Background: In Graves¡¯s disease, there is a lack of description specific to the gender and age among sub-Saharan African subject. The objective was to evaluate the impact of gender and age on the profile of Graves¡¯ disease in Senegalese subject in order to understand the evolution and improve the therapeutic choices. Methods: This is a retrospective study conducted from January 1, 2010 to December 31, 2017 (07 years) at Abass Ndao University Hospital (Senegal), focused on patients with Graves¡¯ disease followed up under antithyroid drugs treatment for at least 18 months. Results: There were 244 men, 404 subjects between [0 - 25 years], and 101 subjects more than 50 years old. Factors associated with goitre size were male gender (p < 0.001), young age (p < 0.001). Graves orbitopathy was correlated with male gender (p = 0.015), and young age (p < 0.001). Among 580 patients who had stopped medical treatment after more than 18 months of follow-up, relapse involved in 30.3%. Durable remission was achieved in 38.8% of all included patients and 69.7% of subjects who had a cessation of medical treatment. The factors associated with sustained remission were female gender (p = 0.049), absence of orbitopathy (p = 0.011), small goiter (p < 0.001), advanced age (p = 0.006) and early start of the maintenance treatment (p = 0.006). Conclusion: In our Senegalese study, men and young patients are particularized by a trend of voluminous goitre and low rate of remission. These data remain a basis for predicting the outcome of medical treatment and make timely use of radical treatments such as surgery or irratherapy in the presence of risk factors for recurrence. %K Graves¡¯s Disease %K Profile %K Gender %K Age %K Senegal %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=100092