%0 Journal Article
%T Botulinum Toxin Type A and Its Possible Mechanisms on Wound Healing
%A Khushboo Gurung
%A Qian Tan
%A Ye Xu
%A Bingchen Duan
%J Modern Plastic Surgery
%P 38-55
%@ 2164-5280
%D 2020
%I Scientific Research Publishing
%R 10.4236/mps.2020.103006
%X Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, <i>Clostridium botulinum</i>. The toxin is now widely and efficiently used in treating a plethora of diverse symptoms and conditions. Recent evidence in the literature also shows that BTX-A exhibits a wide range of effects on non-neuronal cells. Its potential has markedly expanded to clinical applications other than the treatment of neurological and muscular conditions that are characterized by neuronal hyperactivity. A number of studies have shown BTX-A to improve the quality of scar outcome and prevent the formation of keloids and HTS. Although the mechanism of action of BTX-A on wound healing is still not clearly understood, lately there has been extensive research to grasp the underlying mechanisms of this multifunctional toxin. BTX-A seems to affect wound healing by a number of mechanisms that include action on tensile forces, inhibition of fibroblasts differentiation, downregulation of TGF-<i><span style=\"white-space:nowrap;\">¦Â</span></i>1 and collagen expression. This review will explore the responses of Botulinum toxin type-A on wound healing and preventing pathological scars like HTS and keloids, and comprehend the overall effect BTX-A has on wound healing.
%K Wound Healing
%K Botulinum Toxin Type-A
%K Hypertrophic Scar
%K Keloid
%K Fibroblast
%K Myofibroblasts
%K Transforming Growth Factor &lt
%K i&gt
%K &amp
%K #946
%K &lt
%K /i&gt
%K -1
%K Collagen
%K Metalloproteinases
%K Connective Tissue Growth Factor
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=100008