%0 Journal Article
%T LRP<sub>5</sub> Affects Homeostasis of the Periodontal Complex
%A Joo-Hyung Kim
%A Ye-Hyun Kim
%A Won Hee Lim
%J Open Journal of Stomatology
%P 29-37
%@ 2160-8717
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojst.2020.103004
%X <strong>Purpose:</strong> The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP<sub>5</sub>) in this process by removing LRP<sub>5</sub>, and observing the effects of LRP<sub>5</sub> depletion on cells of the periodontal structures. <strong>Material and Methods:</strong> The function of this LRP<sub>5</sub> was evaluated by conditional elimination of the LRP<sub>5</sub> gene using an Osteocalcin Cre driver. The <em>OCN-Cre</em>;&nbsp;<img src=\"Edit_ea3fd2a8-4e52-4060-8d7a-4f00cfd45ac3.png\" alt=\"\" /> mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. <strong>Results:</strong> Elimination of LRP<sub>5</sub> in the periodontal complex of <em>OCN-Cre</em>;&nbsp;<img src=\"Edit_467f5470-a481-40c0-a71e-4861ecc5f9a1.png\" alt=\"\" />&nbsp;mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament.<strong> Conclusion:</strong> Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP<sub>5 </sub>in homeostasis of the periodontal ligament.
%K LRP&lt
%K sub&gt
%K 5&lt
%K /sub&gt
%K Periodontal Ligament
%K Homeostasis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=98905