%0 Journal Article
%T 1-苄基哌啶衍生物的合成研究<br>The Synthesis of 1-Benzylpiperidine Derivatives
%A 王君
%A 陈子仁
%A 刘晨江
%J Studies in Synthetic Chemistry
%P 7-10
%@ 2332-7960
%D 2019
%I Hans Publishing
%R 10.12677/SSC.2019.72002
%X 以1-苄基哌啶酮为原料，先与苯胺和三甲基硅氰发生Strecker反应得到化合物2，再经过酰胺化、甲酯化、N-丙酰化等三步反应，以26%的总收率合成了1-苄基哌啶酮衍生物，产物结构经1H NMR、13C NMR和HRMS表征。该方法具有绿色、简便的特点。<br />
The compound 2 was prepared by the Strecker reaction of 1-benzylpiperidone with aniline and trimethylsilyl cyanide. Then 1-benzylpiperidone derivatives were synthesized in 26% overall yield by amidation, methyl esterification and N-propionylation. The structure of the product was characterized by 1H NMR, 13C NMR and HRMS. The method is green and simple.
%K 1-苄基哌啶，衍生物，合成，表征<br>1-Benzylpiperidine
%K Derivative
%K Synthesis
%K Characterization
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=30643