%0 Journal Article
%T 血压波动与青光眼的联系——昼夜血压波动是开角型青光眼、正常眼压型青光眼发生的危险因素的系统评价和meta分析<br>The Relationship of Blood Pressure with POAG and NTG: A Systematic Review and Meta-Analysis
%A 卢叶
%A 张晓辉
%J Hans Journal of Ophthalmology
%P 141-151
%@ 2167-6550
%D 2019
%I Hans Publishing
%R 10.12677/HJO.2019.84023
%X <div style=\"text-align:justify;\">
	目的：通过meta分析分别研究组间昼夜收缩压、舒张压及其波动幅度的差异，了解系统血压的高低及其昼夜血压波动幅度对开角型青光眼发病的影响。方法：检索Cochrane library，Web of Science，PubMed， MEDLINE，CNKI和美国国立卫生研究院试验注册平台(www.clinicaltrials.gov)等数据库，查找自1990年5月起至2019年4月的关于POAG、NTG和血压波动的相关文献。通过STORBE statement观察性研究评价方法对文献进行评估，涉及315名参与者的5篇文献满足条件纳入分析。结果：开角型青光眼患者和对照组之间昼夜平均收缩压、舒张压差异不具有显著性，昼夜收缩压波动不具有显著性。青光眼患者的舒张压波动幅度(Z = 2.99, p = 0.003 &lt; 0.05)高于对照组，差异有显著性，具有统计学意义。结论：昼夜舒张压波动与原发性开角型青光眼(Primary Open Angle Glaucoma, POAG)和正常眼压性青光眼(Normal Tension Glaucoma, NTG)密切相关，这被高度提示其为POAG和NTG的发病危险因素。<br />
Purpose: We aimed to estimate the differences of systolic blood pressure, diastolic blood pressure, and fluctuation amplitudes between groups to find out the relationship of BP with POAG and NTG by systematic review and meta-analysis. Methods: We had searched Cochrane library, Web of Science, PubMed, MEDLINE database, CNKI and clinicaltrials.gov register platform to find relevant controlled trials ranging from May 1990 to April 2019. Five studies, including 315 individuals, were identified by STROBE statements had been analyzed. Results: For the relationship, only the nocturnal diastolic pressure fluctuation of POAG and NTG was statistically significantly fluctuate larger than negative controls (mean difference 2.41, 95% credible interval [CrI] 0.08 to 4.0). No statistical differences were found in systolic blood pressure, diastolic blood pressure, and nocturnal systolic blood pressure fluctuation. Conclusion: The nocturnal diastolic pressure fluctuation is closely related to POAG and NTG, which is highly inferred to be a risk factor to POAG and NTG.
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%K 开角型青光眼，正常眼压型青光眼，动态血压，血压波动，Meta分析<br>Primary Open Angle Glaucoma
%K Normal Tension Glaucoma
%K Systolic Blood Pressure
%K Diastolic Blood Pressure
%K Meta-Analysis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=33343