%0 Journal Article
%T Impact of Age on Hormonal Profiles of Sub-Fertile Women Attending Fertility Clinic in Umuahia, Abia State, South Eastern Nigeria
%A Ebirien-Agana S. Bartimaeus
%A Chukwuma E. J. Obi
%A Felix U. Igwe
%A Edna O. Nwachuku
%J Open Journal of Internal Medicine
%P 51-68
%@ 2162-5980
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojim.2020.101006
%X <strong>Aim:</strong> This study evaluated the impact of age on the hormonal profiles of women diagnosed with infertility in a Fertility Clinic in Abia State, South-East, Nigeria. <strong>Methodology:</strong> Subjects comprised of 200 females: 150 subjects and 50 controls, aged &lt; 20 and up to 49 years, stratified into age &lt; 20 years (control), age 20 - 29 years (group 1), age 30 - 39 years (group 2) and age 40 - 49 years (group 3). About 5 ml of blood samples for anti-Mullerian, follicle stimulating, luteinizing, estradiol, and prolactin hormones determinations were collected on day 2 - 3 of spontaneous menstrual cycle from all groups and control and analyzed using enzyme-linked immunosorbent assay. The FSH/LH ratio of all groups was also calculated. The data were analyzed statistically and values considered significant at p &lt; 0.05. <strong>Result:</strong> The means ¡À SEM of serum anti-Mullerian hormones were 1602.44 ¡À 54.42 pg/ml (control), 848.06 ¡À 23.04 pg/ml (group 1), 26.74 ¡À 1.28 pg/ml (group 2), 10.37 ¡À 1.26 pg/ml (group 3) values for follicle stimulating hormone in the control subjects was 4.90 ¡À 0.22 mIU/ml, 12.59 ¡À 0.79 mIU/ml (group 1), 30.59 ¡À 1.31 mIU/ml (group 2), and 41.59 ¡À 1.59 miU/ml (group 3). Similarly, the mean ¡À SEM of luteinizing hormone of control, group 1, group 2 and group 3 were 5.01 ¡À 0.22 mIU/ml, 15.02 ¡À 1.13 mIU/ml, 42.71 ¡À 1.82 mIU/ml and 58.22 ¡À 2.62 mIU/ml respectively while for estadiol the values were 63.16 ¡À 1.95 pg/ml, 94.10 ¡À 5.56 pg/ml, 58.84 ¡À 4.01 pg/ml and 36.7 ¡À 1.59 pg/ml for control, group 1, group 2 and group 3 respectively. The mean ¡À SEM of FSH/LH ratio for the control and experimental subjects were 0.98 ¡À 0.01, 0.89 ¡À 0.02, 0.74 ¡À 0.03 and 0.75 ¡À 0.02 for control, group 1, group 2 and group 3 respectively. The comparison of the means showed significant difference (p &lt; 0.0001). The hormonal parameters were also positively and negatively correlated amongst each. <strong>Conclusion:</strong> The evaluation of levels of the hormonal parameters across the age ranges of the population studied shows that women within the control and experimental group 1 (&lt;20 years and 20 - 29 years) have a better chance of achieving pregnancy naturally.
%K Anti-Mullerian Hormone
%K Estradiol
%K Follicle Stimulating Hormone
%K Prolactin
%K Luteinizing Hormone
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=98654