%0 Journal Article
%T Can Gd-EOB-DTPA Affect Proton Density Fat Fraction Using 6-Point DIXON Methods? A Multicenter, Multivendor Phantom Study
%A Tatsuya Hayashi
%A Kei Fukuzawa
%A Hidekazu Yamazaki
%A Takashi Konno
%A JunĄ¯ichi Kotoku
%A Satoshi Saitoh
%J Open Journal of Radiology
%P 9-15
%@ 2164-3032
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojrad.2020.101002
%X <strong>Purpose:</strong> To evaluate the influence of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) on proton density fat fraction (PDFF) using multiple vendorsĄ¯ DIXON methods in a multicenter, multivendor phantom study.<strong> Materials and Methods:</strong> Pairs of phantoms with varying fat volume percentages (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-DTPA concentrations (0 and 0.4 mM) were constructed. The phantom without Gd-EOB-DTPA in each pair was defined as the precontrast phantom, and the corresponding phantom with Gd-EOB-DTPA in each pair was defined as the postcontrast phantom. The phantoms were scanned via three vendorsĄ¯ DIXON techniques to determine PDFFs. Agreement between PDFFs determined in precontrast and postcontrast phantoms was evaluated via Bland¨CAltman analysis. <strong>Results:</strong> Mean differences (precontrast PDFF - postcontrast PDFF) and limits of agreement were Philips 5.1% (<span style=\"white-space:nowrap;\">&amp;minus;</span>0.8% to 11.0%), Siemens 6.1% (<span style=\"white-space:nowrap;\">&amp;minus;</span>0.9% to 13.1%), and GE 1.3% (<span style=\"white-space:nowrap;\">&amp;minus;</span>1.2% to 3.9%). <strong>Conclusions:</strong> PDFFs measured using the three vendorsĄ¯ DIXON techniques were smaller in the postcontrast phantoms than in the corresponding precontrast phantoms regardless of different scanning parameters, because T1 bias was improved by Gd-EOB-DTPA.
%K Dixon
%K Fat
%K Liver
%K MRI
%K Phantom
%K Quantification
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=98246