%0 Journal Article
%T Predictive Significance of IL-17A Serum Levels during Chemotherapy in Senegalese Women with Cervical Cancer
%A Folly Mawulolo Gaba
%A Babacar Mbengue
%A Maimouna Diop
%A Doudou Diouf
%A Sidy Ka
%A Doudou Georges Massar Niang
%A Ramatoulaye Ndiaye
%A Ibrahima Mounkeila Seydou
%A Jean Pascal Demba Diop
%A Moustapha Mbow
%A Rokhaya Ndiaye Diallo
%A Maguette Sylla Niang
%A Mback¨¦ Sembene
%A Ahmadou Dem
%A Alioune Dieye
%J Open Journal of Immunology
%P 37-47
%@ 2162-4526
%D 2019
%I Scientific Research Publishing
%R 10.4236/oji.2019.94004
%X <strong>Background and Objectives:</strong> Cervical cancer is a leading cause of cancer death in female populations. It is a virally induced carcinoma resulting from sexually transmitted high risk Human Papillomavirus infections (e.g. HPV-16, HPV-18). Previous studies have shown associations between IL-17A levels in cancer micro-environments and metastasis of tumor cells. In Africa, chemotherapy (CT) is the standard first-line treatment for cervical cancer and the prognosis remains poor for metastatic and recurrent cases. The impact of CT as a treatment option is still unclear. We investigated the prognostic relevance of IL-17A profiles in Cervical cancer patients (CP) patients treated with cisplatin in combination with 5-fluouracil (5FU) for three cycles. <strong>Methods:</strong> The study included 57 CP and 59 women with no history of malignancy as healthy controls (HC). IL-17A plasma levels were evaluated by ELISA. For each CP, three blood samples were collected at three-week intervals before initiation of the chemotherapy protocol. <strong>Results:</strong> Before chemotherapy CP showed higher serum levels of IL-17A compared to HCs (p = 0.035). No relation was detected between age and IL-17A levels. We observed a significant increase in serum IL-17A during treatment of the CP group (p &lt; 0.05). Depending on chemotherapy¡¯s efficacy, CP were divided into 1) non responders, 2) partial responders and 3) good responders. Non-responders patients showed significantly higher serum levels of IL-17A during the follow-up compared to partial and good responder groups both following the first CT cycle (p &lt; 0.05) and the second CT cycle (p &lt; 0.03). <strong>Conclusion:</strong> Our results suggest that high serum levels of IL-17A are associated with poor responses to classical chemotherapy. However, considering these results to design CC biomarkers, we need further investigations particularly about the relevant prognostic indicator following chemotherapy.<audio controls=\"controls\" style=\"display:none;\"></audio>
%K Cervical Cancer
%K Chemotherapy
%K Interleukin 17A
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=97838