%0 Journal Article
%T Mortality and Thromboembolic Events in Hypercoagulable States from Rotational Thromboelastography (ROTEM) in  Patients Who Undergo Coronary  Bypass Surgery
%A Sira Laohathai
%A Piya Samankatiwat
%J World Journal of Cardiovascular Surgery
%P 133-142
%@ 2164-3210
%D 2019
%I Scientific Research Publishing
%R 10.4236/wjcs.2019.910015
%X <div style=\"text-align:justify;\">
	<strong style=\"line-height:1.5;\">Purpose</strong><span style=\"line-height:1.5;\"><strong>:</strong></span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">This study is to identify the prevalence of preoperative hypercoagulability
in Thailand high</span><span style=\"line-height:1.5;\">-</span><span style=\"line-height:1.5;\">risk population assessed by Rotational thromboelastography (ROTEM) and
test hypothesis that the pre</span><b style=\"line-height:1.5;\">-</b><span style=\"line-height:1.5;\">surgical ROTEM status</span><span style=\"line-height:1.5;\">es</span><span style=\"line-height:1.5;\"> are related to MACCE
at 1, 12, 60 months after coronary bypass graft surgery (CABG). <b>Method</b></span><b style=\"line-height:1.5;\">:</b><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">This is a prospective
cohort in consecutive patients who underwent on-pump CABG between 2013-2015.
Blood sampling</span><span style=\"line-height:1.5;\">s</span><span style=\"line-height:1.5;\"> were collected and analyzed using ROTEM preoperatively. Hypercoagulable
state was defined as any clotting time (CT) or</span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">clot formation time (CFT)
below the lower normal limit or amplitude 10 min after CT (A10), Maximum clot
firmness</span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">(MCF)</span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">in ROTEM measurement </span><span style=\"line-height:1.5;\">is</span><span style=\"line-height:1.5;\"> above the upper normal limit of EXTEM, INTEM and
FIBTEM</span><span style=\"line-height:1.5;\">.</span><span style=\"line-height:1.5;\"> <b>Results</b></span><b style=\"line-height:1.5;\">:</b><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">43</span><span style=\"line-height:1.5;\">% </span><span style=\"line-height:1.5;\">of CABG patients who
were diagnosed as hypercoagulability state assessed by ROTEM</span><span style=\"line-height:1.5;\">. </span><span style=\"line-height:1.5;\">Mortality rate was
slightly higher in hypercoagulable patients without statistical significance
(9% vs 5.1%; P = 0.461)</span><span style=\"line-height:1.5;\">.</span><span style=\"line-height:1.5;\"> However, overall combined uneventful rate was significantly increased in
hypercoagulable patients in 5 years follow-up (27.2% vs 8.6%; P = 0.012). In
univariate analysis, ROTEM hypercoagulability is associated major
%K Hypercoagulable Stage
%K CABG
%K ROTEM
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=95457