%0 Journal Article
%T Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats
%A Loyce Nakalembe
%A Josephine N. Kasolo
%A Edward Nyatia
%A Aloysius Lubega
%A Godfrey S. Bbosa
%J Neuroscience & Medicine
%P 259-271
%@ 2158-2947
%D 2019
%I Scientific Research Publishing
%R 10.4236/nm.2019.103020
%X <strong>B</strong><strong>ackgroun</strong><strong>d:</strong> Pain is a common problem encountered in daily life among humans and animal and it is commonly managed conventionally using modern medicines and traditionally by use of medicinal plants. <em>Phytolacca dodecandra</em> is a common herb in Uganda, used traditionally to alleviate pain and inflammatory conditions. However, its activity in alleviating pain and inflammatory diseases has not been fully scientifically evaluated. <strong>Aim of Study:</strong> To evaluate the analgesic and anti-inflammatory activity of total crude leaf extracts of<em> P. dodecandra</em> in Wistar albino rats. <strong>Materials and Methods:</strong> It was a laboratory-based experimental study. Acetic acid-induced writhing test was used to determine the analgesic activity and the histamine-induced paw edema formation for anti-inflammatory activity of the extract. Twenty eight animals were divided into 7 groups each with 4 rats and two (2) sets of data were obtained from each animal per group as per guidance of the refinement rule of 3Rs. For analgesic activity, Group I was dosed with 1.0ml of normal saline (negative control), group II, III, IV, V, VI were dosed with 1000.0, 600.0, 150.0, 40.0 and 5.0 mg/kg bwt of extract respectively. Group VII was dosed 10.0 mg/kg bwt diclofenac sodium (Na) drug (positive control). For anti-inflammatory activity, Group I was dosed with 1.0ml of normal saline (negative control), Group II, III, IV, V, VI were dosed with 1000.0, 600.0, 300.0, 40.0 and 5.0 mg/kg bwt of extract respectively. Group VII was dosed 10.0 mg/kg bwt diclofenac Na. The percentage mean paw volume inhibition and percentage writhing protection were determined. <strong>Results:</strong> The mean percentage paw volume inhibitions were 29.1%, 74.2% and 32.3% at doses of 5.0, 40.0 mg/kg bwt and 10.0 mg/kg bwt diclofenac Na respectively. The mean percentage writhing protection was 8.9%, 10.4%, 78.5% and 98.7% at doses of 150.0, 600.0, 1000.0 mg/kg of extract and 10.0 mg/kg bwt diclofenac Na respectively. <strong>Conclusions:</strong> Total crude leaf extracts of <em>P. dodecandra</em> has analgesic and anti-inflammatory activity that may be attributed to the presence of polyphenolic, saponins and many others phytochemicals that are present in the plant.
%K &lt
%K i&gt
%K Phytolacca dodecandra&lt
%K /i&gt
%K Analgesic
%K Anti-Inflammatory
%K Total Crude
%K Leaf Extract
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=95217