%0 Journal Article
%T IMPROVING THE ANTIBACTERIAL ACTIVITY BY THE COMBINATION OF ZIRCONIUM OXIDE NANOPARTICLES (ZrO2)AND CEFTAZIDIME AGAINST KLEBSIELLA PNEUMONIAE
%A Sarah Naji Aziz
%A Karrar Jasim Al-Sallami
%A Suhad Yassein Abd
%A AliMuhsin AliAl-Musawi
%A Murtadha Adnan Mohammed
%A Al-Maamoon H. Abed
%A Sundus Qasim Mohammed
%J global journal of public health medicine
%R -
%X Introduction:Klebsilla  pneumoniae isoneofmust  opportunisticpathogens  that  causesnosocomial infection, UTI,respiratory tract  infections and blood  infections.ZrO2nanoparticleshave antimicrobial activityagainst   some   pathogenic   bacteria   and   fungi. Ceftazidimeis   one   of   third   generation cephalosporinsgroups of antibiotecs, characterized by its broad spectrum on bacteria in general and particularly on Enterobacteriaceaefamily like Klebsiellaspp.Method:DiverseclinicalsamplesofKlebsilla  pneumoniae were  isolated  from  several  hospitals  in Baghdad ¨CIraqand ZrO2nanoparticles was investigatedagainstit.Ceftazidimewas also investigated against K.pneumoniae.  Both  ofZrO2nanoparticles  and ceftazidime  were  mixed  together  andinvestigatedagainstK.pneumoniae.Results: The result  showed  that ZrO2nanoparticles  were  effectivity  on  inhibiting  opportunisticpathogens.  By  using zirconium  oxide  nanoparticleson Klebsiella pneumonia isolatesin  24h.  of incubationtime, inhibition  zones  were  (38,34,10,10,8,0)  mm respectively  on  agar  plates.  By  using ceftazidime alone against the samebacteriainhibition zones were (40,32,10,9,8,0) mm.respectively.Conclusion:The present study results that the antibacterial activity of ceftazidime against bacteria was increased  when  combination  between ZrO2nanoparticles and  the  antibiotic  had  done,  because, inhibition zones in case of mixing both of ZrO2nanoparticles and ceftazidime were (43,40,12,12,10,0) mm respectively. So that we can conclude that the combination of zirconium oxide nanoparticles (ZrO2)and ceftazidime was a useful methodfor the treatment of Klebsilla pneumoniathat causenosocomial infection, UTI,respiratory tract infections and blood infections.
%K ZrO2nanoparticles
%K Klebsiellapneumoniae
%K antibacterial activity
%K ceftazidime.
%U https://www.gjphm.org/index.php/gjphm/article/view/4