%0 Journal Article
%T COX-2抑制剂在肿瘤治疗领域的研究进展<br>Research Progress of COX-2 Inhibitors in the Field of Tumor Therapy
%A 王岩
%A 王世玲
%A 房子怡
%A 郭晓莹
%A 秦洁
%J Hans Journal of Medicinal Chemistry
%P 45-50
%@ 2331-8295
%D 2019
%I Hans Publishing
%R 10.12677/HJMCe.2019.73008
%X <div style=\"text-align:justify;\">
	阿司匹林上市后，COX-2抑制剂进一步发展，成为消炎，镇痛和治疗风湿及类风湿性关节疾病的主流药物。然而，近些年研究发现，COX-2抑制剂不仅能应用于抗炎领域，也可以应用在肿瘤预防和治疗方面。这一点在分子生物学和细胞生物学的研究中也得到了证实。在单独给药和联合用药的研究中，COX-2抑制剂均表现出了良好的肿瘤抑制效果。本文关于COX-2基因的表达，COX-2抑制剂的作用机制和目前的应用的研究进程进行综述。<br />
Since the launch of aspirin, COX-2 inhibitors have further developed into mainstream drugs for anti-inflammatory, analgesic and rheumatic joint diseases. However, studies in recent years have found that COX-2 inhibitors can not only be applied in the field of anti-inflammatory, but also in the field of tumor prevention and treatment. This has been demonstrated in molecular biology and cell biology. COX-2 inhibitors have shown good tumor inhibition effects on both single and combined drug administration studies. In this paper, the expression of COX-2 gene, the mechanism of COX-2 inhibitor and its current application were reviewed.
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%K COX-2抑制剂，肿瘤治疗<br>COX-2 Inhibitor
%K Cancer Treatment
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=31839