%0 Journal Article
%T The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>
%A Priscila Medeiros
%A Sylmara Esther Negrini-Ferrari
%A Ana Carolina Medeiros
%A Lais Leite Ferreira
%A Josie Resende Torres da Silva
%A Jos¨¦ Aparecido da Silva
%A Norberto Cysne Coimbra
%A Renato Leonardo de Freitas
%J World Journal of Neuroscience
%P 138-152
%@ 2162-2019
%D 2019
%I Scientific Research Publishing
%R 10.4236/wjns.2019.93009
%X <div style=\"text-align:justify;\">
	<strong style=\"line-height:1.5;\">Background</strong><span style=\"line-height:1.5;\">:</span><span style=\"line-height:1.5;\"></span><span style=\"line-height:1.5;\"> The primary motor
cortex (M<sub>1</sub>) stimulation (MCS) is a useful tool for attenuation of
the peripheral neuropathic pain in patients with pharmacologically refractory
pain. Furthermore, that neurological procedure may also cause antinociception
in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding
in patients with neuropathic pain, then, we evaluated if an adapted model of
neuropathy induced by chronic constriction injury (CCI) of the <i>ischiadicus</i> <i>nervus</i> (</span><a name=\"_Hlk5892330\"></a><span style=\"line-height:1.5;\">sciatic nerve</span><span style=\"line-height:1.5;\">) produces cold allodynia in an animal model of chronic pain. In
addition, we also investigated the effect of the electrical stimulation of the
M<sub>1</sub> on chronic neuropathic pain condition in laboratory animals. <b>Methods:</b> Male Wistar rats were used. An adapted model of peripheral mononeuropathy
induced by CCI was carried out by placing a single loose ligature around the
right sciatic nerve. The acetone test was used to evaluate the cold allodynia
in CCI or Sham (without ligature) rats. The MCS (M<sub>1</sub>) was performed
at low-frequency (20</span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">¦ÌA, 100 Hz) during </span><span style=\"line-height:1.5;\">15</span><span style=\"line-height:1.5;\"> </span><span style=\"line-height:1.5;\">s by
deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham
procedures. The cold allodynia was measured before and immediately after the
neurostimulation of M<sub>1</sub> in the following time-window: 0, 15 and 30
min after MCS.</span><span style=\"line-height:1.5;\"> </span><b style=\"font-family:'';font-size:10pt;line-height:1.5;\">Results:</b><i style=\"font-family:'';font-size:10pt;line-height:1.5;\"><span \"=\"\"> </span></i><span style=\"line-height:1.5;\">Cold
allodynia threshold increased in animals with chronic neuropathic pain
submitted to the acetone test 21 days after the CCI surgery. The M<sub>1</sub>-stimulation
by DBS procedure decreased the cold allodynia immediately and until 30 min
after M<sub>1</sub>-stimulation in rats with chronic neuropathic pain.</span><span style=\"line-height:1.5;\"> </span><b style=\"font-family:'';font-size:10pt;line-height:1.5;\">Conclusion: </b><span style=\"line-height:1.5;\">The current
proposal
%K Peripheral Neuropathic Pain
%K Chronic Pain
%K Sciatic Nerve
%K Chronic  Constriction Injury
%K Cold Allodynia
%K Primary Motor Cortex Stimulation
%K Antinociception
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=94119