Landscape segmentation and classification is fundamental to landscape research because it provides an important frame of reference for researchers to communicate and compare their work. Anthropogenic human activities mainly lead to landscape changes. The present study aims to assess the impact of anthropogenic activities on landscape classification of the Nile Delta using remote sensing and GIS techniques. Field survey, digital databases and GIS capabilities are applied for landscapes classification. Vector data using a lot of maps and raster data using satellite image have the ability to give obvious classification about landscape. Results showed that the anthropogenic impacts affect negatively on the landscape classification. Using GF2, landscapes are classified into major eight classes: cultivated land, garden land, woodland, grassland, bare land, urban land, water bodies and mining land. It was showed that the urban occupies the highest percentage of the study area. Urban construction and development areas centered on the capital Cairo city and the city of Giza are dumbbell-shaped to the east. Bare lands occupy the second percentage of the study area, and it may be distributed on around the Nile Delta, southeast of Cairo City and southwest of Giza City. According to vegetation cover, three classes were applied as the sequence: Cultivated land > Garden land > Grass land. These classes depend mainly on the River Nile. Vegetation cover may be based mainly %K Landscape %K Nil Delta %K GIS %K Metrics %K GF2 %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=93845