%0 Journal Article
%T Progress toward the Synthesis of Pochonin J
%A Sydney N. Jackson
%A Rongson Pongdee
%J International Journal of Organic Chemistry
%P 96-105
%@ 2161-4695
%D 2019
%I Scientific Research Publishing
%R 10.4236/ijoc.2019.92009
%X The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using EvansĄŻ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.
%K Natural Products
%K Pochonin J
%K Resorcylic Acid Lactones
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=92985