%0 Journal Article
%T A New Regimen in the Treatment of Psoriasis Using Oral Methotrexate
%A Khalifa E. Sharquie
%A Adil A. Noaimi
%A Mays H. Alobaidi
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 165-176
%@ 2161-4512
%D 2019
%I Scientific Research Publishing
%R 10.4236/jcdsa.2019.92014
%X <strong>Background:</strong> Methotrexate is a well-known standard therapy for psoriasis. The standard regimen is using six (2.5 mg) tablets/week that might be with many side effects. <strong>Objective:</strong> Finding a new regimen for oral methotrexate aiming to decrease side effects and increase its effectiveness. <strong>Patients and Methods:</strong> This therapeutic, comparative study done at the Center of Dermatology, Medical city, from October 2017 to October 2018. Fifty-three patients with moderate to severe psoriasis completed the study. They were divided into: Group (A) (27) patients were treated with the new oral regimen and Group (B) (26) patients were treated with the six tablets/week. Investigations including CBC, LFT and RFT were done. PASI score, BSA and side effects especially gastrointestinal ones were recorded.<strong> Results:</strong> They were 29 males and 24 females. Age ranged from 18 - 67 years. Disease duration ranged from 1 - 30 years. BSA involved ranged from 20% - 79%. The PASI score ranged from 10.2 - 45.7. After 8 weeks of treatment, there was statistically significant difference (p-value &gt; 0.001) regarding PASI score and gastrointestinal side effects being less in Group (A). Group A patients were more satisfied. <strong>Conclusion:</strong> The new regimen used in the present study has lower gastrointestinal side effects and more efficacy.
%K Psoriasis
%K Methotrexate
%K New Regimen
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=92898